Side Effects Game

Side Effects: Survive the Deadliest Pill Roulette

Side Effects is a tense, experimental game of chance where only one test subject survives. Inspired by Buckshot Roulette, this medical trial simulator blends strategy, bluffing, and sheer luck. Will you outlast your opponent—or overdose trying?

Take Pills or Take a Risk

Each round, you and your opponent take turns consuming mysterious pills from a shared tray. Every pill affects your stats—some boost, some harm, and others might be fatal. It’s a gamble every time you choose. Your goal? Stay alive longer than your rival.

Use Items Strategically

Throughout the trial, you’ll gain access to items that offer slight advantages or shift the odds in your favor. Use them wisely—they can help you recover tolerance, peek at pills, or sabotage your opponent. Every choice matters.

Monitor Your Tolerance

Tolerance is key in Side Effects. The more pills you take, the more your body resists—or reacts. Mismanaging this system could result in an instant loss. Watching your numbers while predicting your rival’s next move creates intense, strategic tension.

Prototype Built with Personality

Side Effects was built in just 10 days, and while it’s a prototype, it already offers gripping, replayable rounds of deadly decision-making. The visuals are intentionally rough, enhancing its experimental vibe. The AI isn’t perfect, but human vs. human games shine with bluffing and psychological tension.

Why Side Effects Stands Out

Short, sharp rounds. Simple mechanics. Deep risk-reward decisions. Side Effects delivers the kind of minimalist, high-stakes gameplay that sticks with you. And while the web version is solid, downloading the full version offers smoother visuals and a better overall experience.